Disulfide Bond Cleavage of Human Fibrinogen by cis-Diamminedichloroplatinum (II).
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منابع مشابه
Synthesis of Zinc Dimethyldithiocarbamate by Reductive Disulfide Bond Cleavage of Tetramethylthiuram Disulfide in Presence of Zn2+
The zinc(II) complex [Zn2(dmdtc)2(μ-dmdtc)2] has been synthesized directly from thiram ligand, containing a disulfide bond {dmdtc = N,N-dimethyldithiocarbamate; thiram = N,N-tetramethylthiuram disulfide}, and characterized by elemental analysis and spectroscopic methods. Surprisingly thiram, undergoes a reductive disulfide bond scission upon reaction with Zn2+ in methanolic media to give the [Z...
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the zinc(ii) complex [zn2(dmdtc)2(μ-dmdtc)2] has been synthesized directly from thiram ligand, containing a disulfide bond {dmdtc = n,n-dimethyldithiocarbamate; thiram = n,n-tetramethylthiuram disulfide}, and characterized by elemental analysis and spectroscopic methods. surprisingly thiram, undergoes a reductive disulfide bond scission upon reaction with zn2+ in methanolic media to give the [z...
متن کاملCleavage by restriction enzymes of DNA modified with the antitumour drug cis-diamminedichloroplatinum(II).
The effect of binding of an antitumour drug cis-diamminedichloroplatinum(II) (cis-[Pt(NH3)2Cl2]) to DNA on cutting effectiveness of BamHI, EcoRI, and SalI restriction endonucleases was quantitatively determined. The platinum complex inhibits the cleavage of plasmid pHC624 DNA linearized by BglI restrictase. From the present results we conclude that the yield of restriction endonuclease cleavage...
متن کاملsynthesis of zinc dimethyldithiocarbamate by reductive disulfide bond cleavage of tetramethylthiuram disulfide in presence of zn2+
the zinc(ii) complex [zn2(dmdtc)2(μ-dmdtc)2] has been synthesized directly from thiram ligand, containing a disulfide bond {dmdtc = n,n-dimethyldithiocarbamate; thiram = n,n-tetramethylthiuram disulfide}, and characterized by elemental analysis and spectroscopic methods. surprisingly thiram, undergoes a reductive disulfide bond scission upon reaction with zn2+ in methanolic media to give the [z...
متن کاملSelective reduction of cis-diamminedichloroplatinum(II) nephrotoxicity by ebselen.
2-Phenyl-1,2-benzisoselenazol-3(2H)-one (ebselen) is classified as a relatively nontoxic selenium compound, probably because of its bound selenium moiety. In thiol-rich tissues, such as the kidneys, ebselen is converted into selenol intermediates. Selenols are nucleophilic agents which might be able to react with platinum compounds. The influence of ebselen on cis-diamminedichloroplatinum(II) (...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1992
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.15.611